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Intensity of behavioral disturbances and seizure presentation assessment After paracetamol application, intensity of progressing behavioral disturbances and seizure presentation was continuously monitored, and assessed and scored (score 0 - normal, score 1 - rearing on hind legs, shaking, 2 - sleepy, tottering walk, 3 - sleepy, tottering walk and repeatedly falling down, 4 - sleepy, tottering walk and repeatedly falling down, jerking of the extremities, 5 - lying down, generalized convulsions) at particular time points depending on the regimen used, as described before

Acknowledgements We would wish to thank the patients for the fibroblast donation and for their participation during the Exenatide-PD clinical trials

Some more stable peptides can last 4-6 weeks, while fragile ones may show significant degradation by week 2

doi: 10.1016/j.tibs.2009.02.004